Maybe Glycation isn't so bad after all

Higher HbA1c levels predict better outcomes in advanced heart failure with diabetes  (free registration required)

"We're finding that in heart failure [plus diabetes], higher HbA_1C levels are associated not with worse outcomes, but with better outcomes," lead investigator Dr Tamara Horwich (University of California, Los Angeles) told heartwire. This suggests that for patients with both diseases, "the focus should not be on lowering the HbA_1C levels to as low as possible," she said, adding that "aiming for a midrange of 7.2% to 8.2% may be very reasonable."

OK, this is in people with established heart disease and diabetes, but lower is, apparently, not always better.  And what is it we keep hearing about all these damaged metabolisms and all ...