A Friday JAMA-lama Ding Dong!

Well ... I wasn't really going to weigh in further past using that recent JAMA article (EDIT:  full text no longer free at JAMA, see link below) as an example of where statistics can lead us astray.  But ... as is probably expected, this study has kicked up some dust in the community.  I'm sure I'll miss a few, but here's the weighing in so far:

Stephan Guyenet

Anthony Colpo

Marion Nestle

Don Matesz

Fat Head

That's just the blog posts, not the tweets, FB postings or other social media buzz ... and I'm happy to edit in more, just drop the hint in comments.  And here's the full text of the study:  Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance

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Fat Tissue Regulation ~ Part IX: ASP, LPL and the Triglyceride/Fatty Acid Cycle

In this installment, we reunite with our old friend C3KO mouse to learn a little bit more about the role of acylation stimulating protein, ASP, in the regulation of fat tissue (and muscle) from this study:  Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP.  The C3KO mouse was discussed in Part II of this series.  This mouse lacks the gene to produce a protein called C3 (short for Complement 3) which is a precursor for the formation of ASP.  Thus C3KO mice are ASP deficient.  The C3KO is to ASP as a type1 diabetic is to insulin.  These mice are also resistant to obesity.  BTW, hyperASPemia accompanies the hyperinsulinemia and hyperleptinemia of obesity when it's measured.

ASP-deficient mice have delayed postprandial triglyceride (TG) clearance and reduced WAT mass. The objective of this study was to examine the mechanism(s) by which ASP deficiency induces differences in postprandial TG clearance and body composition in male KO mice.

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