I'm working on a post about hyperinsulinemia and obesity in humans. It may well turn into several posts. But in one study I will be discussing they identified hypersecreters according to something called the corrected insulin response, CIR. Sometimes this is further "standardized" as the CIRgp which is evaluated at the peak glucose reading. The CIR is value calculated following a standard OGTT. If you have data from your OGTT, you can calculate your own and determine how you rank.
The CIR was developed by Sluiter and colleagues as outlined in: Glucose Tolerance and Insulin Release, A Mathematical Approach I. Assay of the Beta-cell Response After Oral Glucose Loading.
From the dose-response relations between glucose and insulin after oral glucose loading, a reproducible parameter for beta-cell response was deduced. The main advantage of this parameter lies in its independence from the initial or reached glucose level.
 |
| Units: glucose in mg/dL , insulin in μU/mL |
