A slight detour in my current endeavors to put forth some information regarding the etiology of diabetes, insulin resistance and β-cell function, before I get to the two major reviews that prompted this.
To review, in my last post, discussing this paper, a seminal observation/conclusion can be summed up as follows: Insulin is formed in stepwise fashion from a larger protein (preproinsulin) that has a terminal signaling chain cleaved forming proinsulin that is then folded, cross-linked and has one of the three main chains cleaved in the last step(s) resulting in a protein with two parallel chains, insulin. I like this newer representation I found below because it provides the numbers in the amino acid sequence at which the cuts are made. This is important to better understanding the papers I'm going to discuss here.
To review, in my last post, discussing this paper, a seminal observation/conclusion can be summed up as follows: Insulin is formed in stepwise fashion from a larger protein (preproinsulin) that has a terminal signaling chain cleaved forming proinsulin that is then folded, cross-linked and has one of the three main chains cleaved in the last step(s) resulting in a protein with two parallel chains, insulin. I like this newer representation I found below because it provides the numbers in the amino acid sequence at which the cuts are made. This is important to better understanding the papers I'm going to discuss here.
