A while back I asked if anyone had any evidence that insulin blocks leptin action in the brain. There were many responses both here and on Twitter -- thanks!! -- one of which referenced the following study: Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults, PA Velasquez-Mieyer, PA Cowan, KL Arheart, CK Buffington, KA Spencer, BE Connelly, GW Cowan, and RH Lustig. If you're the person pointed me to this, I apologize for not naming you. Ahhhh Robert Lustig. Haven't spent much time on him here, but as he muscles his way into the (misguided) War on Insulin, this too shall change.
I will have much more to say about that study on the whole at some future date. They gave some people an insulin-lowering drug (a drug that does more than just suppress secretion) and some lost "significant" weight, some lost a wee bit, and some even gained weight. In reading the intro, I'm becoming increasingly dejected over the quality of peer review these days ... but that too will be part of the subsequent analysis of this study as a whole.
