Coming next in the discussion of diabetes I am going to discuss insulin secretion in greater detail. I was reminded of this post in the writing process. So ... Bump!
Original Publish Date: 4/4/11
Chronic Exposure to Free Fatty Acid Reduces Pancreatic β-Cell Insulin Content by Increasing Basal Insulin Secretion That Is Not Compensated For by a Corresponding Increase in Proinsulin Biosynthesis Translation
JD McGarry contributing author.
Original Publish Date: 4/4/11
Chronic Exposure to Free Fatty Acid Reduces Pancreatic β-Cell Insulin Content by Increasing Basal Insulin Secretion That Is Not Compensated For by a Corresponding Increase in Proinsulin Biosynthesis Translation
JD McGarry contributing author.
{Please note: Excerpts from the text will be edited somewhat to avoid "cluttering" references, statistical values, and some rounding of numbers. Text will sometimes be presented in bullet form or with paragraph breaks to ease reading. It is not my intent to plagiarize nor to alter the content. If anyone feels I've altered the content in any meaningful way, do please let me know!} Direct quotes will be indented.
FFA are an important physiological fuel for islets, and act as a supplemental nutrient secretagogue to potentiate insulin release acutely in the presence of glucose.
Translation: β-cells run on fatty acids but this fuel also serves to stimulate insulin secretion.
